Arene C–H functionalisation using a removable/modifiable
Feb 04, 2016 (PDF) Synthetic Methods Use of a Traceless Activating and This method takes advantage of the nitro group as a traceless activating and directing group (TADG) that is released in the aromatization step to produce 4-substituted 3-perfluoroalkyl pyrazoles ChemInform Abstract: Traceless Directing Group for
Abstract Picolinamide has first been employed as a traceless directing group for the cobalt-catalyzed oxidative annulation of benzylamides with alkynes to synthesize isoquinolines through C–H/N–H bonds activation. Oxygen is used as a terminal oxidant. This protocol exhibits good functional group tolerance and excellent regioselectivity.
The phenomenon of a 1,5-sigmatropic hydrogen shift or a 1,5-sigmatropic methyl shift was observed in this reaction depending on the different substituent groups such as R3 in the o Chem Soc Rev - pdfs.semanticscholar.org and directing group removal of functionalised product 21 can be carried out in one-pot. In some cases, the directing group introduction can also be done in the same pot. Such directing groups are classified as traceless. Given the rapid expansion of this still growing field, it is not possible to cover all of the representative chemistry in the
The present disclosure is directed to a traceless directing group in a radical cascade. The chemo- and regioselectivity of the initial attack in skipped oligoalkynes is controlled by a propargyl alkoxy moiety. Radical translocations lead to the boomerang return of radical center to the site of initial attack where it assists to the elimination of the directing functionality via β-scission in
US9676679B2 - Traceless directing groups in radical The present disclosure is directed to a traceless directing group in a radical cascade. The chemo- and regioselectivity of the initial attack in skipped oligoalkynes is controlled by a propargyl alkoxy moiety. Radical translocations lead to the boomerang return of radical center to the site of initial attack where it assists to the elimination of the directing functionality via β-scission in